GameLoop is an Android emulator that is used as a gaming platform.
It is one of the best Android emulator for PC that offers custom key mapping for keyboard configurations. Refer this page for a list of titles that require disabling it.Bluestacks is a very popular Android emulator. Disable it only when running a game that requires it.
OpenGL should be avoided on AMD and Intel GPUs on Windows due to poorly optimized drivers. Direct3D 11 is a good fallback option for stability or compatibility reasons.